She started her career by winning the third cycle of America's Next Top Model.
She hosted the first season of the Oxygen reality series Hair Battle Spectacular in 2010.
In August 2013, Marcille appeared in the video clip "J'accélère (I accelerate)" by French rapper Rohff.
On August 5, 2015, Marcille stars in the main cast as the role of Tara in the TV One series Born Again Virgin.
In February 2016 she stars in a reality series called About the business.
Furthermore, she has appeared in several music videos, including "Baby" by Angie Stone (featuring Betty Wright), 50 Cent's "I Get Money" and Jamie Foxx's "DJ Play a Love Song".