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Systems of staging may differ between diseases or specific manifestations of a disease.

Within the TNM system, a cancer may also be designated as recurrent, meaning that it has appeared again after being in remission or after all visible tumor has been eliminated.

However, clinical staging and pathologic staging often complement each other.

Not every tumor is treated surgically, therefore pathologic staging is not always available.

Oversight of one cell can mean mistaging and lead to serious, unexpected spread of cancer.